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Effect of auranofin on the disulfide reductase activities of mitochondrial TGR. An enzyme aliquot (about 25 ng) was preincubated at 25°C in the presence of 100 μM NADPH and inhibitor as described under Materials and Methods. To start the reaction either GSSG or DTNB was added. Final concentrations of the disulfide substrate were 40 μM GSSG (
); and 1 mM DTNB (
).
