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. Author manuscript; available in PMC: 2010 Aug 23.
Published in final edited form as: Annu Rev Genomics Hum Genet. 2009;10:387–406. doi: 10.1146/annurev.genom.9.081307.164242

Figure 5. Genome coverage as a function of reference panel size.

Figure 5

The accuracy of imputation increases with the number of individuals in the reference panel. To generate the figure, we analyzed genotyped data from the FUSION study (93). For any given r2 threshold, the results illustrate the proportion of markers whose genotypes can be imputed with equal or greater accuracy. The results illustrate how the proportion of markers whose genotypes are recovered accurately (with high r2 between imputed and actual genotypes) increases with larger reference panels.