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Cell surface pro-PrP is using the GPI-PSS as a transmembrane domain. The GPI-PSS transverses the membrane and interacts with FLNa. The ABD of FLNa binds actin filaments. The normal PrP is GPI-anchored and glycosylated.
ABD: Actin-binding domain; GPI: Glycosylphosphatidylinositol; PrP: Prion protein; PSS: Peptide signal sequence.
