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. Author manuscript; available in PMC: 2010 Aug 23.
Published in final edited form as: Arch Neurol. 2008 May 12;65(7):896–905. doi: 10.1001/archneur.2008.65.7.nct70006

Table 2.

Mean Changes From Baseline in Cognitive Function by Treatment Group

Measure Treatment Group
Celecoxib
 Naproxen Sodium
 Placebo
 P Value
No. of
Participants		 Mean Change
in Score (SD)		 No. of
Participants		 Mean Change
in Score (SD)		 No. of
Participants		 Mean Change
in Score (SD)		 Celecoxib
vs Placebo		 Naproxen
vs Placebo
Global summary, y
 1 608 −0.04 (0.40) 589 −0.06 (0.39) 889 −0.03 (0.39) .61 .15
 2 432 −0.05 (0.45) 424 −0.07 (0.45) 629 −0.02 (0.40) .22 .07
 3 195 −0.01 (0.44) 202 −0.10 (0.51) 303 −0.04 (0.42) .47 .12
Adjusted 3MS-E, y
 1 608 −0.79 (3.22) 589 −0.67 (3.47) 889 −0.46 (3.22) .06 .21
 2 432 −1.19 (4.28) 424 −0.95 (4.03) 629 −0.50 (3.41) .004 .06
 3 195 −1.03 (3.53) 202 −1.39 (4.84) 303 −0.99 (3.59) .92 .28
GVF, y
 1 608 −0.01 (5.38) 589 −0.06 (5.76) 889 0.32 (5.59) .25 .19
 2 432 −0.38 (5.66) 424 −0.81 (5.79) 627 −0.01 (5.45) .29 .02
 3 195 −0.18 (5.10) 202 −0.60 (6.02) 303 −0.33 (6.02) .77 .61
RBMT delayed recall, y
 1 608 −0.05 (3.39) 589 −0.27 (3.19) 889 0.04 (3.26) .59 .08
 2 432 −0.15 (3.28) 424 0.17 (3.39) 628 0.02 (3.29) .41 .47
 3 195 0.35 (3.12) 201 0.16 (2.73) 303 0.26 (2.79) .73 .70
BVMT-R delayed recall, y
 1 608 −0.15 (2.25) 589 −0.22 (2.35) 889 −0.20 (2.14) .69 .87
 2 431 −0.17 (2.50) 424 −0.23 (2.44) 628 −0.28 (2.39) .46 .74
 3 195 0.14 (2.59) 202 −0.24 (2.57) 302 0.04 (2.36) .64 .22
Adjusted HVLT-R trial 4, y
 1 608 0.02 (2.32) 589 −0.07 (2.46) 888 −0.11 (2.29) .30 .78
 2 432 0.00 (2.36) 424 −0.03 (2.66) 628 0.07 (2.41) .62 .51
 3 195 −0.12 (2.28) 202 −0.22 (2.65) 303 −0.18 (2.26) .80 .85
Digit Span, forward, y
 1 607 0.00 (1.74) 589 0.07 (1.71) 889 0.02 (1.73) .88 .56
 2 430 0.09 (1.70) 422 −0.03 (1.82) 627 0.11 (1.86) .83 .22
 3 195 0.07 (1.71) 202 −0.19 (1.74) 303 0.06 (1.80) .92 .13
Digit Span, backward, y
 1 606 0.05 (1.68) 589 −0.04 (1.72) 889 0.00 (1.76) .53 .69
 2 430 0.20 (1.75) 423 −0.05 (1.70) 625 0.09 (1.84) .33 .19
 3 195 0.17 (1.82) 202 −0.04 (2.01) 302 −0.03 (1.65) .23 .95

Abbreviations: BVMT-R, Brief Visuospatial Memory Test–Revised; GVF, generative verbal fluency; HVLT-R, Hopkins Verbal Learning Test–Revised; RBMT, Rivermead Behavioral Memory Test; 3MS-E, Modified Mini-Mental State Examination.