Figure 1. UCP2 is expressed in mouse and human mast cells.
(A). RT-PCR for UCP2 and β-actin. Lane 1, cDNA from BMMCs; lane 2, pooled cDNA from mouse brown fat, liver, brain and muscle for positive control; lane 3, BMMC mRNA not reverse transcribed for negative control. Images are representative of three separate experiments with similar results. (B) Immunoblot of lysate from wild-type BMMCs, Ucp2−/− BMMCs and LAD2 cells using antibody against UCP2. Immunoblot is representative of three experiments with similar results. (C) Representative May-Grünwald/Giemsa staining of wild-type and Ucp2−/− BMMCs. Original magnification, 100x. (D) Flow cytometry of the surface expression of c-Kit and FcεRI in wild-type and Ucp2−/− BMMCs. Dotted lines are BMMCs incubated with isotype control antibody. Data is representative of three experiments with similar results.