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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Org Lett. 2010 Jul 2;12(13):2904–2907. doi: 10.1021/ol1006604

Table 4.

Benzylation of benzothiaoxazepine-1,1-dioxides

graphic file with name nihms211406u3.jpg
SM R1 R2 R3 R4 pdt yield (%)[a]
9a 4-Br Ph H Bn 10a 99
9a 4-Br Ph H 3,5-diMeO-Bn 10b 72
9a 4-Br Ph H 4-F Bn 10c 85
9b 4-Br iBu H 4-F Bn 10d 97
9b 4-Br iBu H 2-Me Bn 10e 81
9c 3-Cl iBu H 4-Cl Bn 10f 76
9d 5-Cl Me Ph 2-Me Bn 10g 78
9d 3-Cl Me Ph 2-Me Bn 10h 83
[a]

Yields after filtration through a SiO2 SPE.