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. 2009 Jul 6;2009:951548. doi: 10.4061/2009/951548

Figure 1.

Figure 1

A proposed mechanism of mitochondrial induced cell death in Alzheimer's disease. Legend: Aβ; amyloid-β; ROS reactive oxygen species; ETC electron transport chain; mtPTP mitochondrial permeability transition pore; C cytochrome c ; IMM inner mitochondrial membrane; OMM outer mitochondrial membrane; APP amyloid precursor protein; TOM and TIM protein importation translocases of the mitochondrial outer and inner membranes. For further details, see text. (Modified from Mancuso M et al., Antioxid Redox Signal 2007;9:1631–1646).