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. Author manuscript; available in PMC: 2010 Aug 23.
Published in final edited form as: Oncogene. 2008 Dec;27(Suppl 1):S114–S127. doi: 10.1038/onc.2009.49

Fig. 1. Domain structure of BNIP3 subfamily members.

Fig. 1

(A). The BH3 domain, the conserved domain (CD), the trans-membrane domain (TM), and the conserved Cys residue implicated in stabilization of the BNIP3 homodimers are indicated. The coordinates of ceBNIP3 are based on the ORF described by Yasuda et al (Yasuda et al., 1998a). The ORF described by Cizeau et al (Cizeau et al., 2000) contains an extra 11-amino acid region at the N-terminus. (B). The amino acid sequence of the BH3 domain and the conserved domain are indicated. A conserved Trp residue within the BH3 domain of all BNIP3 related proteins is indicated by (*). In the bottom panel the BH3 domain of BNIP3 is compared with the BH3 domain of BAD to highlight the Ser residue. (C). The amino acid sequences of the TM domain and the sequence elements that mediate homodimerization are shown.