Table 3.
Case–control comparison of FRMD4B variant allele frequencies. p values are by Fisher’s exact test. ND is not detected. Top, all‐cause heart failure (significant p < 0.008). Bottom, heart failure by etiology (significant p < 0.004).
| SNP ID | Codon | Primary study | Second study | ||||
|---|---|---|---|---|---|---|---|
| Controls (n= 625) | Heart Failure (n= 1,117) | p value | Controls (n= 311) | Heart Failure (n= 502) | p value | ||
| 217 | L73V | 0.0258 | 0.0341 | 0.1858 | ND | ND | |
| rs4361282 | E173D | 0.24 | 0.2249 | 0.3146 | 0.1991 | 0.2298 | 0.1556 |
| rs62254461 | L236L | 0.1146 | 0.1094 | 0.6531 | 0.1473 | 0.113 | 0.0382 |
| rs13059488 | L331L | 0.9603 | 0.9679 | 0.2491 | 0.9818 | 0.9698 | 0.1445 |
| rs9831516 | S947L | 0.977 | 0.9793 | 0.6274 | 0.9956 | 0.9892 | 0.2717 |
| 3055 | E1019K | 0.0114 | 0.0114 | 1 | ND | ND | |
| SNP ID | Codon | Controls (n= 625) | Ischemic (n= 691) | p value | Nonischemic (n= 426) | p value | |
| 217 | L73V | 0.0258 | 0.0337 | 0.2109 | 0.0346 | 0.2371 | |
| rs4361282 | E173D | 0.2400 | 0.2155 | 0.1487 | 0.2402 | 1.0000 | |
| rs62254461 | L236L | 0.1146 | 0.1160 | 0.9513 | 0.0987 | 0.2830 | |
| rs13059488 | L331L | 0.9603 | 0.9672 | 0.3465 | 0.9692 | 0.2849 | |
| rs9831516 | S947L | 0.9770 | 0.9774 | 0.8969 | 0.9824 | 0.4393 | |
| 3055 | E1019K | 0.0114 | 0.0115 | 1.0000 | 0.0114 | 1.0000 | |