Table 1.
Clinical and plasma parameters of the study population
| All individuals | Individuals without type 2 diabetes and NASH | Type 2 diabetes patients | NASH patients | Individuals with type 2 diabetes and NASH | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. of individuals/Mean (SD) | Minimal/maximal values | No. of individuals/Mean (SD) | Minimal/maximal values | No. of individuals/Mean (SD) | Minimal/maximal values | No. of individuals/Mean (SD) | Minimal/maximal values | No. of individuals/Mean (SD) | Minimal/maximal values | |
| Number of individuals | 75 | 29 | 25 | 41 | 20 | |||||
| Male/female | 22/53 | 7/22 | 7/18 | 12/29 | 4/16 | |||||
| Age (years) | 44.4 (9.9) | 17 - 67 | 40.3 (9.2) | 17 - 54 | 48.2 (9.4) | 28 - 67 | 45.8 (8.9) | 28 - 65 | 46.5 (8.1) | 28 - 65 |
| BMI (kg/m2) | 46.5 (9.6) | 34.6 - 73.6 | 42.6 (6.5) | 34.6 - 56.8 | 49.4 (11.4) | 34.8 - 73.6 | 48.7 (10.8) | 34.8 - 73.6 | 49.6 (12.1) | 34.8 - 73.6 |
| Glucose (mmol/l) | 6.60 (2.1) | 4.3 - 14.5 | 5.53 (0.49) | 4.3 - 6.5 | 8.73 (2.5) | 4.3 - 14.5 | 7.16 (2.56) | 4.3 - 14.5 | 8.8 (2.72) | 4.3 - 14.5 |
| Insulin (mU/l) | 19.3 (10.9) | 3.8 - 53 | 16.7 (8.8) | 5.6 - 37 | 20.6 (13.1) | 5.5 - 53 | 20.9 (11.1) | 3.8 - 49 | 20.4 (10.9) | 3.8 - 49 |
| HbA1c | 6.58 (1.39) | 5.1 - 12.1 | 6 (0.54) | 5.1 - 7.2 | 7.9 (1.78) | 5.3 - 12.1 | 6.88 (1.65) | 5.2 - 12.1 | 7.85 (1.88) | 5.2 - 12.1 |
| Total cholesterol (mmol/l) | 5.08 (1.1) | 3 - 9.8 | 4.93 (0.65) | 3.5 - 6.1 | 5.15 (1.43) | 3.5 - 9.8 | 5.08 (1.23) | 3 - 9.8 | 5.2 (1.5) | 3 - 9.8 |
| HDL cholesterol (mmol/l) | 0.98 (0.38) | 0.5 - 2.8 | 1.05 (0.3) | 0.6 - 1.9 | 0.8 (0.23) | 0.5 - 1.3 | 0.93 (0.44) | 0.5 - 2.8 | 0.78 (0.22) | 0.5 - 2.8 |
| LDL cholesterol (mmol/l) | 3.22 (1.02) | 1.1 - 7.4 | 3.16 (0.86) | 1.1 - 4.3 | 3.29 (1.18) | 1.5 - 7.4 | 3.17 (1.06) | 1.5 - 7.4 | 3.32 (1.25) | 1.5 - 7.4 |
| TG (mmol/l) | 2.26 (2.12) | 0.63 - 16.4 | 1.67 (0.95) | 0.63 - 4.2 | 3.31 (3.46) | 0.88 - 16.4 | 2.73 (2.71) | 0.88 - 16.4 | 3.56 (3.67) | 0.88 - 16.4 |
| NEFA (mmol/l) | 0.64 (0.32) | 0.12 - 1.66 | 0.52 (0.34) | 0.12 - 1.66 | 0.72 (0.3) | 0.16 - 1.33 | 0.71 (0.28) | 0.21 - 1.33 | 0.76 (0.29) | 0.21 - 1.33 |
| ALAT (U/l) | 25.7 (16.5) | 6 - 124 | 19.8 (6.3) | 7 - 37 | 32.3 (23.1) | 10 - 124 | 27.7 (19.3) | 6 - 124 | 32.4 (24.8) | 6 - 124 |
| ASAT (U/l) | 25.3 (12.9) | 7 - 72 | 21.1 (11.6) | 7 - 50 | 28.9 (15.4) | 8 - 72 | 28.4 (13) | 8 - 72 | 30.7 (16) | 8 - 72 |
| CRP (mg/l) | 10.2 (8.5) | 1 - 37 | 9.9 (9.2) | 1 - 37 | 13.1 (10) | 1.7 - 35 | 10 (8.2) | 1.7 - 35 | 12.8 (10.2) | 1.7 - 35 |
Data are means ± standard deviation (SD) and the minimal and maximal values for each trait. Data are given for all individuals, individuals without type 2 diabetes or NASH, type 2 diabetes patients, NASH patients, and individuals with both type 2 diabetes and NASH. Patients with type 2 diabetes are 36, 37, 40, 42, 43, 49, 51, 54, 55, 57, 60, 63, 64, 65, 69, 75, 77, 78, 79, 85, 87, 97, 101, 103, and 110 - IDs are concordant with the IDs used submitted to the Gene Expression Omnibus database. Patients with NASH are 38, 42, 43, 44, 45, 47, 49, 51, 52, 53, 54, 57, 58, 60, 62, 63, 64, 65, 69, 72, 75, 78, 79, 83, 85, 87, 88, 92, 93, 95, 97, 99, 100, 101, 102, 103, 104, 105, 107, 110, and 113. TG, triglycerides; NEFA, non-esterified fatty acid; ALAT, alanine aminotransaminase; ASAT, aspartate aminotransaminase; CRP, C-reactive protein; NASH, non-alcoholic steatohepatitis.