Table 4.

Over-represented Panther biological processes in modules correlated to a metabolic trait in subcutaneous (SAT) and visceral adipose tissue (VAT)

	SAT Module 4		SAT Module 8		VAT Module 9
	No. of genes in module	P-value	No. of genes in module	P-value	No. of genes in module	P-value
Total	308		87		103
Signal transduction	67	2.8 × 10-4	NA	NS	NA	NS
- Intracellular signalling cascade	26	2.0 × 10-3	NA	NS	NA	NS
Immunity and defense	43	3.5 × 10-9	31	4.1 × 10-17	21	8.2 × 10-7
- T-cell-mediated immunity	13	9.2 × 10-5	7	6.4 × 10-4	NA	NS
- MHCII-mediated immunity	NA	NS	5	2.5 × 10-5	NA	NS
- Macrophage-mediated immunity	NA	NS	7	7.5 × 10-5	5	3.3 × 10-2
- Endocytosis	NA	NS	7	6.2 × 10-3	NA	NS
- B-cell and antibody-mediated immunity	7	2.4 × 10-2	4	4.9 × 10-2	NA	NS
- Complement mediated immunity	NA	NS	4	2.4 × 10-3	NA	NS
Transport	41	2.8 × 10-7	NA	NS	16	1.2 × 10-3
- Ion transport	23	1.8 × 10-4	NA	NS	NA	NS
Cell adhesion	20	1.6 × 10-3	NA	NS	11	9.2 × 10-4
Lipid, fatty acid and steroid metabolism	21	9.7 × 10-3	NA	NS	NA	NS
Carbohydrate metabolism	19	2.5 × 10-3	NA	NS	NA	NS
Other	89	NA	37	NA	44	NA
Unclassified	76	NA	19	NA	24	NA

SAT modules 4 and 8 correlate to HDL, and VAT module 9 correlates to glucose. The modules SAT 12, SAT 39, VAT 40 do not contain enough genes to perform a reliable pathway analysis. The modules correlated to gender in both tissues consist solely of Y-chromosomal genes and are not included in the table.

Only biological functions that are over-represented in a module after Bonferroni correction are shown. For each over-represented biological function the number of genes in the module that belong to this biological function, and the corresponding Bonferroni corrected p-value for over-representation are shown. The number of genes that are part of a class which is not over- or under-represented, and the number of genes that could not be classified by PANTHER are also shown for each module ("other" and "unclassified" respectively). NA, not applicable; NS, not significant.