Table 1.
Comparisons of anthropometric and metabolic characteristics among 3 genotypes at rs2283228
| Genotype | P | |||
|---|---|---|---|---|
| rs2283228 | AA | AC | CC | |
| Numbers | 156 | 191 | 51 | |
| Sex, male (n/%) | 77/49.3 | 90/47.1 | 27/52.9 | 0.746 |
| Age, years | 51.67 ± 5.50 | 51.28 ± 5.47 | 52.53 ± 5.72 | 0.836 |
| Hypertension, n/% | 83/53.2 | 121/63.3 | 31/60.7 | 0.155 |
| Type 2 diabetes mellitus, n/% | 21/13.5 | 29/15.2 | 7/13.7 | 0.894 |
| Family history of CAD, n/% | 64/41.0 | 73/38.2 | 17/33.3 | 0.609 |
| Smokers, n/% | 53/33.9 | 69/36.1 | 17/33.3 | 0.887 |
| BMI, kg/m2 | 24.29 ± 3.46 | 24.93 ± 3.81 | 24.33 ± 3.00 | 0.227 |
| FBS, mmol/L | 5.73 ± 1.72 | 5.57 ± 0.98 | 5.87 ± 1.86 | 0.408 |
| Insulin, mU/L | 14.31 ± 11.87 | 13.16 ± 9.84 | 17.32 ± 13.08 | 0.351 |
| HOMA-IR | 3.64 ± 0.59 | 3.56 ± 0.57 | 4.36 ± 0.83 | 0.138 |
| TC, mmol/L | 4.65 ± 0.93 | 4.39 ± 0.86 | 4.63 ± 0.78 | 0.116 |
| TG, mmol/L | 1.53 ± 0.76 | 1.50 ± 0.80 | 2.03 ± 0.84 | 0.007 |
| LDL-C, mmol/L | 2.82 ± 0.80 | 2.71 ± 0.74 | 2.74 ± 0.84 | 0.604 |
| HDL-C, mmol/L | 1.21 ± 0.30 | 1.14 ± 0.25 | 1.07 ± 0.22 | 0.052 |
| Apo A1, g/L | 1.15 ± 0.18 | 1.11 ± 0.19 | 1.08 ± 0.16 | 0.055 |
| Apo B, g/L | 0.87 ± 0.25 | 0.86 ± 0.25 | 0.97 ± 0.23 | 0.115 |
Data are mean ± SD, or number (%), as appropriate.
P is the significance level of comparison of clinical and plasma parameters among 3 groups by one-way ANOVA or chi-square test.
Apo A1, apolipoprotein A1; Apo B, apolipoprotein B; BMI, body mass index; CAD, coronary artery disease; FBS, fasting blood sugar; HDL-C, high-density lipoprotein cholesterol; HOMA-IR, homeostasis model assessment-insulin resistance; LDL-C, low-density lipoprotein cholesterol; SNPs, single nucleotide polymorphisms; TC, total cholesterol; TG, triglyceride.