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Diabetogenic and antidiabetogenic actions of ghrelin.
| Prodiabetic effects | Antidiabetic effects |
|---|---|
| stimulation of hepatic glucose output | chronic ↑ GH (lipolysis) |
| adipogenesis* | increase lean-body mass (chronic) |
| inhibition of insulin secretion | decrease oxygen consumption |
| appetite enhancement | increase uncoupling protein-1 |
| acute free-fatty acid release* (human) | |
| Antithermogenesis | |
| decreased sympathetic outflow |
