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TBAR measurements following Exendin-4 treatment reveals that high-dose therapy resulted in significant reduction in oxidative stress. The experiment was designed as described in Materials and Methods and Figs. 1 and 2. The data displayed are mean values ± SE for ob/ob mice treated with low-dose and high-dose Exendin-4 and saline. Values are compared with those of saline-treated ob/ob mice.
