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. Author manuscript; available in PMC: 2010 Aug 23.
Published in final edited form as: Vaccine. 2008 Dec 16;27(7):1040–1049. doi: 10.1016/j.vaccine.2008.11.099

Fig. 3.

Fig. 3

Vaccination of mice and macaques with TA-CIN in GPI-0100 adjuvant induces HPV16 E6- and E7-specific antibody. (A) Groups of Balb/c mice (n = 5) were vaccinated s.c. three times at two-week intervals with TA-CIN (20 μg) alone, or with GPI-0100 (50 μg) or with GPI-0100 and Tween 40 (1 μg). ELISA was performed using HPV16 E6 or HPV16 E7 protein to detect specific serum antibody at one month after the third immunization using sera pooled from each group. ELISA was performed using HPV16 E6 (B) or HPV16 E7 (C) protein to detect specific serum antibody obtained from macaques 746, 811 and 831 at one month after 1, 2 or 3 immunizations with 125 μg of TA-CIN with 1000 μg GPI-0100 that were initiated at week 0.