Figure 3.
A) Time course of relative luminal diameter. VEGF at 10−8 M was applied at the time indicated by the arrow. Rapamycin or rapamycin vehicle was applied intraperitoneally at 24-hour and again 1-hour before VEGF application. Data are mean±SEM. R.: Rapamycin.
B) Effect of Rapamycin on VEGF-induced arterial vasodilation at 30-min after VEGF application. Maximal mean relative luminal diameter responses are shown. Data are mean±SEM. Numbers in parentheses show number of animals. *P<0.05 compared with rapamycin vehicle.