A) Syntenic regions of the human and mouse genomes containing KLF1, compared with the region of the chicken genome containing the gene presently called KLF1 (shown as KLF17*) and regions of the human, mouse and frog genomes containing the KLF17 gene. Chicken KLF17 is syntenic with KLF17 in other species but not with mammalian KLF1. B) Relatedness between the chicken KLF17 protein versus KLF1 and KLF17 proteins from other species. Chicken KLF17 is 29.2% identical to human KLF1 across the entire protein, but only 17.5% identical to human KLF17 (asterisks, red numbers). The chicken KLF17 DNA binding domain shows 85.7% identity with human KLF1 but only 58.3% identity with human KLF17 (asterisks, blue numbers).