Figure 1.

Sites of HuR phosphorylation by DNA damage-inducible kinases. Schematic of HuR depicting the RNA recognition motifs (RRMs, dark blue), the hinge region (brown) with the HuR nucleocytoplasmic shuttling sequence (HNS), the sites of phosphorylation (under “Phosphorylated Amino Acids”), and the DNA Damage-Regulated Kinases responsible, including an unknown kinase predicted to phosphorylate S242. The consequences of HuR phosphorylation at the different sites are indicated under “Impact on HuR Function”. More details in the text.