Table 3.
Histomorphometric analysis 2, 5 and 10 weeks after fracture of perindopril-treated and untreated animals
| Histomorphometry |
2 weeks |
5 weeks |
10 weeks |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Perindopril | Control | P | Perindopril | Control | P | Perindopril | Control | P | |
| Gap width (mm) | 0.2 ± 0.0 | 0.2 ± 0.0a | 0.29 | 0.0 ± 0.0 | 0.2 ± 0.1 | <0.001 | 0.0 ± 0.0 | 0.0 ± 0.0 | 1.00 |
| Cl.Dm/F.Dm (%) | 211.3 ± 16.1 | 151.1 ± 17.3 | 0.02 | 164.1 ± 9.5 | 127.8 ± 8.6 | <0.05 | 139.4 ± 6.0 | 137.7 ± 9.5 | 0.89 |
| Pc.Ar (mm2) | 5.2 ± 0.6 | 2.1 ± 0.8 | <0.01 | 3.2 ± 0.5 | 1.0 ± 0.4 | <0.01 | 2.6 ± 0.4 | 2.5 ± 0.5 | 0.79 |
| Bone/Pc.Ar (%) | 42.9 ± 7.7 | 36.7 ± 10.4 | 0.64 | 96.4 ± 3.6 | 90.9 ± 9.1 | 0.53 | 100.0 ± 0.0 | 100.0 ± 0.0 | 1.00 |
| Cartilage/ Pc.Ar (%) | 40.5 ± 6.9 | 19.9 ± 9.4 | 0.10 | 0.3 ± 0.3 | 0.9 ± 0.9 | 0.42 | 0.0 ± 0.0 | 0.0 ± 0.0 | 1.00 |
| F.t./Pc.Ar (%) | 16.6 ± 1.7 | 43.4 ± 16.3 | 0.06 | 3.4 ± 3.4 | 8.3 ± 8.3 | 0.54 | 0.0 ± 0.0 | 0.0 ± 0.0 | 1.00 |
| Healing score | 1.3 ± 0.3 | 0.3 ± 0.2 | <0.01 | 3.8 ± 0.7 | 2.0 ± 0.7 | <0.05 | 4.0 ± 0.0 | 4.0 ± 0.0 | 1.00 |
Data shown in the Table are mean ± SEM.
a
P < 0.05 versus perindopril-treated animals after 5 weeks.
Cl.Dm/F.Dm, maximum callus diameter/femur diameter; F.t., fibrous tissue; Pc.Ar, periosteal callus area.