Table 3.
Common genetic variation of IGFBP1 and IGFBP3 and percent breast density in the Multiethnic Cohort, N=819
| Haplotype block | SNP | N1 | Mean (95% CI) | p-value trend2 | p-value dominant3 | p-value recessive4 |
|---|---|---|---|---|---|---|
| 1 | rs10228265 | 378 | 32.4 (30.5 ; 34.4) | 0,64 | 0,35 | 0,64 |
| 315 | 34.1 (32.0 ; 36.2) | |||||
| 86 | 32.2 (28.2 ; 36.2) | |||||
|
| ||||||
| rs1553009 | 452 | 33.1 (31.3 ; 34.8) | 0,45 | 0,55 | 0,50 | |
| 281 | 32.5 (30.2 ; 34.7) | |||||
| 55 | 31.0 (26.1 ; 36.0) | |||||
|
| ||||||
| rs35539615 | 415 | 32.9 (31.1 ; 34.8) | 0,48 | 0,87 | 0,05 | |
| 295 | 31.8 (29.6 ; 34.0) | |||||
| 61 | 37.4 (32.6 ; 42.2) | |||||
|
| ||||||
| rs2201638 | 703 | 32.9 (31.4 ; 34.4) | 0,50 | |||
| 97 | 31.5 (27.7 ; 35.3) | |||||
|
| ||||||
| rs1065780 | 262 | 34.0 (31.7 ; 36.3) | 0,53 | 0,09 | 0,37 | |
| 365 | 30.8 (28.8 ; 32.7) | |||||
| 143 | 33.7 (30.6 ; 36.8) | |||||
|
| ||||||
| 2 | rs3793344 | 255 | 33.6 (31.2 ; 35.9) | 0,98 | 0,29 | 0,22 |
| 375 | 31.2 (29.2 ; 33.1) | |||||
| 156 | 34.2 (31.2 ; 37.1) | |||||
|
| ||||||
| rs1874479 | 587 | 32.3 (30.7 ; 33.9) | 0,55 | |||
| 197 | 33.3 (30.6 ; 35.9) | |||||
|
| ||||||
| rs4988515 | 778 | 32.7 (31.3 ; 34.1) | 0,70 | |||
| 33 | 34.0 (27.5 ; 40.6) | |||||
|
| ||||||
| rs4619 | 276 | 33.9 (31.6 ; 36.2) | 0,79 | 0,18 | 0,25 | |
| 350 | 31.1 (29.0 ; 33.1) | |||||
| 143 | 34.3 (31.2 ; 37.4) | |||||
|
| ||||||
| rs1908751 | 332 | 33.3 (31.2 ; 35.3) | 0,97 | 0,61 | 0,40 | |
| 347 | 32.1 (30.0 ; 34.1) | |||||
| 89 | 34.4 (30.5 ; 38.4) | |||||
|
| ||||||
| rs1496495 | 564 | 32.4 (30.7 ; 34.0) | 0,55 | 0,39 | 0,60 | |
| 209 | 33.9 (31.4 ; 36.5) | |||||
| 21 | 30.6 (22.5 ; 38.7) | |||||
|
| ||||||
| rs1496497 | 563 | 32.3 (30.7 ; 33.9) | 0,62 | 0,44 | 0,59 | |
| 209 | 33.8 (31.2 ; 36.4) | |||||
| 22 | 30.5 (22.6 ; 38.4) | |||||
|
| ||||||
| rs2270628 | 584 | 32.2 (30.7 ; 33.8) | 0,49 | |||
| 214 | 33.3 (30.7 ; 35.8) | |||||
|
| ||||||
| 3 | rs3110697 | 333 | 32.8 (30.7 ; 34.9) | 0,97 | 0,63 | 0,54 |
| 353 | 31.8 (29.8 ; 33.7) | |||||
| 100 | 33.5 (29.8 ; 37.1) | |||||
|
| ||||||
| rs6953668 | 682 | 32.3 (30.8 ; 33.7) | 0,20 | |||
| 124 | 34.7 (31.3 ; 38.2) | |||||
|
| ||||||
| rs2854747 | 349 | 33.0 (31.0 ; 35.1) | 0,73 | 0,47 | 0,69 | |
| 349 | 31.8 (29.8 ; 33.8) | |||||
| 92 | 33.2 (29.3 ; 37.0) | |||||
|
| ||||||
| rs2854746 | 297 | 33.7 (31.3 ; 36.1) | 0,43 | 0,16 | 0,80 | |
| 333 | 31.3 (29.2 ; 33.3) | |||||
| 159 | 32.6 (29.6 ; 35.6) | |||||
|
| ||||||
| rs2854744 | 320 | 33.9 (31.6 ; 36.1) | 0,68 | 0,16 | 0,32 | |
| 333 | 31.1 (29.1 ; 33.1) | |||||
| 142 | 34.0 (30.8 ; 37.2) | |||||
|
| ||||||
| rs2132570 | 477 | 33.2 (31.4 ; 34.9) | 0,17 | 0,39 | 0,09 | |
| 276 | 32.6 (30.3 ; 34.8) | |||||
| 41 | 27.8 (22.0 ; 33.5) | |||||
|
| ||||||
| rs2471554 | 653 | 32.0 (30.5 ; 33.6) | 0,15 | |||
| 158 | 34.7 (31.6 ; 37.8) | |||||
|
| ||||||
| Outside blocks | rs6670 | 684 | 32.6 (31.1 ; 34.1) | 0,75 | ||
| 121 | 33.2 (29.7 ; 36.8) | |||||
|
| ||||||
| rs2453839 | 548 | 33.7 (32.0 ; 35.3) | 0,01 | 0,04 | 0,02 | |
| 225 | 31.4 (28.9 ; 33.8) | |||||
| 23 | 23.2 (15.4 ; 31.0) | |||||
Mean levels and CIs were adjusted for ethnicity, age, age2 and BMI at the time of each mammogram
number of women for each genotype
p-value for additive mode of inheritance; percent breast density was linearly related to the number of minor alleles (0, 1, or 2)
p-value for dominant mode of inheritance; percent breast density was compared between women who were heterozygous or homozygous for the minor allele and all others
p-value for recessive mode of inheritance; percent breast density was compared between women who were homozygous for the minor allele and all others
BMI=body mass index; CI=confidence interval; SNP=single nucleotide polymorphism