Table 2.
Age-specific ORs for breast cancer among Hispanic and NHW women with at least one-first-degree relative with a history of breast cancer and according to relative’s age at diagnosis of breast cancera
| Family history of breast cancer | Age at diagnosis < 50 years |
Age at diagnosis ≥50 years |
||||||
|---|---|---|---|---|---|---|---|---|
| Case n (%) | Control n (%) | Unadjusted OR (95% CI)b | Adjusted OR (95% CI)c | Case n (%) | Control n (%) | Unadjusted OR (95% CI)b | Adjusted OR (95% CI)c | |
| NHW | ||||||||
| No | 401 (77) | 463 (88) | 1.00 (reference) | 1.00 (reference) | 753 (77) | 878 (84) | 1.00 (reference) | 1.00 (reference) |
| Yes | 122 (23) | 62 (12) | 2.27 (1.63–3.17) | 2.34 (1.64–3.35) | 227 (23) | 168 (16) | 1.58 (1.26–1.97) | 1.69 (1.34–2.13) |
| Relative diagnosed < 50 years | 56 (11) | 23 (4) | 2.81 (1.70–4.65) | 3.02 (1.77–5.16) | 60 (6) | 47 (5) | 1.49 (1.00–2.21) | 1.64 (1.09–2.47) |
| Relative diagnosed > 50 years | 66 (13) | 39 (7) | 1.95 (1.29–2.97) | 1.96 (1.29–3.05) | 163 (17) | 116 (11) | 1.64 (1.27–2.12) | 1.72 (1.32–2.25) |
| Hispanic | ||||||||
| No | 299 (87) | 299 (90) | 1.00 (reference) | 1.00 (reference) | 340 (81) | 466 (85) | 1.00 (reference) | 1.00 (reference) |
| Yes | 45 (13) | 34 (10) | 1.32 (0.82–2.13) | 1.32 (0.82–2.19) | 82 (19) | 82 (15) | 1.37 (0.98–1.92) | 1.47 (1.03–2.10) |
| Relative diagnosed < 50 years | 30 (9) | 22 (7) | 1.36 (0.77–2.42) | 1.35 (0.72–2.52) | 29 (7) | 34 (6) | 1.17 (0.70–1.96) | 1.21 (0.70–2.08) |
| Relative diagnosed > 50 years | 15 (4) | 10 (3) | 1.50 (0.66–3.39) | 1.49 (0.63–3.53) | 52 (12) | 46 (8) | 1.55 (1.02–2.36) | 1.74 (1.11–2.72) |
Women were excluded if they were secondary cases of primary breast cancer (n = 98 NHW and 48 Hispanic), or did not know their family history (n = 51 NHW and 37 Hispanic) or did not self-report as being primarily of NHW or Hispanic ethnicity (n = 36)
OR and 95% CI from an unadjusted, unconditional logistic regression model
OR and 95% CI from an unconditional logistic regression model adjusted for center (Arizona, Colorado, New Mexico, Utah), age (years, continuous), menopausal status at date of diagnosis or referent year (pre, peri, postmenopausal), parity (0, 1–2, 3–4, 5 or more children), age of first birth (<20, 20–24, 25–29, 30 years or more), body mass index at date of diagnosis or referent year (<25, 25–29.9, 30 kg/m2 or more), age of menarche (<12, 12, 13, ≥14 years old), education (did not graduate from high school, high school graduate or equivalent, some college, bachelors degree or higher), and number of first-degree female relatives 50 years of age or older (≤1, 2, 3, ≥4)