Figure 1.

Gut microbiota selectively control colon CB₁ mRNA expression. CB₁ mRNA levels were selectively altered in the colons of mice according to the gut microbiota–host interaction model tested. (A) Colon CB₁ mRNA levels in ob/ob mice fed a normal chow diet (Ob-CT) or treated with prebiotics (Ob-Pre) for 5 weeks (n=10). (B) Colon CB₁ mRNA levels in lean wild-type mice (CT) or after antibiotic treatment (Ab) for 2 weeks (n=8–9). (C) Colon CB₁ mRNA levels in germ-free (GF) mice versus conventionally raised mice (CONV-R) (n=5). (D) Jejunum CB₁ mRNA levels in the same groups of mice described in panels A, B and C. (E) Colon CB₁ mRNA levels in mice fed a normal chow diet (CT) or a high-fat diet (HFD) enriched with or without prebiotics (HFD-Pre) for 14 weeks (n=7–8). (F) Jejunum CB₁ mRNA levels in CT, HFD and HFD-Pre mice (n=7–8). (G) Colon CB₁ mRNA levels in wild-type or Myd88^−/− mice fed an HFD for 8 weeks (n=5). ^*P<0.05 as determined by a two-tailed Student's t-test. Data with different superscript letters were significantly different according to post hoc ANOVA one-way statistical analysis.