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. 2010 Jul 27;6:392. doi: 10.1038/msb.2010.46

Figure 6.

Figure 6

Changes in gut microbiota decrease adiposity and CB1 mRNA expression, and regulate adipogenesis markers. (A) Adiposity index and (B) CB1 mRNA expression levels in the adipose tissue of ob/ob mice fed a normal chow diet (Ob-CT) or treated with prebiotics (Ob-Pre) for 5 weeks (n=10). (C) White adipose tissue AEA (per cent of control values) and FAAH mRNA levels were measured in the same group of mice (n=10). (D) Adipocyte differentiation (PPAR-γ, aP2 and C/EBP-α) and (E) lipogenesis (SREBP-1c, ACC and FAS) mRNA expression levels in the adipose tissue of the same group of mice (n=10). (F) Adipocyte differentiation (PPAR-γ, aP2 and C/EBP-α) mRNA expression levels and (G) lipogenesis (SREBP-1c, ACC and FAS) mRNA expression levels in adipose tissue from obese ob/ob mice treated with vehicle (Ob-CT) or CB1 receptor antagonist (SR141716A) (Ob-SR) (10 mg/kg/day) for 12 days (n=6). *P<0.05 as determined by a two-tailed Student's t-test.