Table 3.
List of IKK/NF-κB target genes in HBMECs, induced by Pf-IRBC or Pf-IRBC-P exposure
| Gene name | Gene symbol | Ratio |
|---|---|---|
| Cytokine, chemokine, and receptors | ||
| Chemokine (C-C motif) ligand 20 | CCL20 | 779.33 |
| Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | CXCL1 | 174.23 |
| Chemokine (C-X-C motif) ligand 2 | CXCL2 | 286.98 |
| Chemokine (C-X-C motif) ligand 3 | CXCL3 | 54.69 |
| Chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) | CXCL6 | 5.99 |
| Interleukin 6 (interferon, beta 2) | IL-6 | 141.15 |
| Interleukin 8 | IL-8 | 132.04 |
| Interleukin 4 receptor | IL-4R | 3.18 |
| Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | ICAM1 | 54.61 |
| Tumor necrosis factor (ligand) superfamily, member 9 | TNFSF9 | 2.91 |
| Tumor necrosis factor receptor superfamily, member 5 | TNFRSF5 | 6.63 |
| Inhibin, beta A (activin A, activin AB alpha polypeptide) | INHBA | 17.46 |
| Leukemia inhibitory factor (cholinergic differentiation factor) | LIF | 7.44 |
| CD44 molecule (Indian blood group) | CD44 | 3.73 |
| Transcription factor and signaling molecules | ||
| Nuclear factor, interleukin 3 regulated | NFIL3 | 3.43 |
| Nuclear receptor subfamily 4, group A, member 1 | NR4A1 | 18.47 |
| Nuclear receptor subfamily 4, group A, member 2 | NR4A2 | 18.69 |
| V-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) | MAFF | 10.12 |
| Jun oncogene | JUN | 7.94 |
| Activating transcription factor 3 | ATF3 | 11.02 |
| Interferon regulatory factor 2 | IRF2 | 2.17 |
| Early growth response 1 | EGR1 | 11.89 |
| Down syndrome critical region gene 1 | DSCR1 | 2.36 |
| Tissue factor pathway inhibitor 2 | TFPI2 | 2.49 |
| TNFAIP3 interacting protein 1 | TNIP1 | 5.89 |
| Tumor necrosis factor, alpha-induced protein 2 | TNFAIP2 | 29.74 |
| Tumor necrosis factor, alpha-induced protein 3 | TNFAIP3 | 26.54 |
| Tumor necrosis factor, alpha-induced protein 6 | TNFAIP6 | 9.01 |
| EH-domain containing 1 | EHD1 | 4.93 |
| Immediate early response 3 | IER3 | 12.01 |
| Immediate early response 5 | IER5 | 2.88 |
| Epstein-Barr virus–induced gene 3 | EBI3 | 6.68 |
| Jumonji, AT-rich interactive domain 1B | JARID1B | 2.23 |
| Baculoviral IAP repeat-containing 3 | BIRC3 | 46.22 |
| BCL2-like 1 | BCL2L1 | 2.97 |
| BCL2-related protein A1 | BCL2A1 | 11.11 |
| Kruppel-like factor 6 | KLF6 | 5.33 |
| Phorbol-12-myristate-13-acetate–induced protein 1 | PMAIP1 | 3.39 |
| Transporter activity | ||
| Solute carrier family 2 (facilitated glucose transporter), member 6 | SLC2A6 | 3.27 |
| Transporter 1, ATP-binding cassette, subfamily B (MDR/TAP) | TAP1 | 5.77 |
| Enzyme activity (eg, kinases, phosphatases) | ||
| Plasminogen activator, tissue | PLAT | 12.56 |
| Plasminogen activator, urokinase | PLAU | 6.24 |
| Mitogen-activated protein kinase kinase 3 | MAP2K3 | 3.12 |
| Protein phosphatase 1, regulatory (inhibitor) subunit 15A | PPP1R15A | 4.38 |
| GTP cyclohydrolase 1 (dopa-responsive dystonia) | GCH1 | 10.19 |
| Dual specificity phosphatase 1 | DUSP1 | 8.26 |
| Interferon-stimulated exonuclease gene 20 kDa | ISG20 | 6.88 |
| Superoxide dismutase 2, mitochondrial | SOD2 | 5.71 |
| Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | TGM2 | 3.49 |
| Others | ||
| Ferritin, heavy polypeptide 1 | FTH1 | 2.1 |
| Growth arrest and DNA-damage–inducible, alpha | GADD45A | 3.2 |
| Major histocompatibility complex, class I, B | HLA-B | 2.38 |
| Pentraxin-related gene, rapidly induced by IL-1 beta | PTX3 | 9.2 |
| Syndecan 4 | SDC4 | 4.89 |
| Zinc finger CCCH-type containing 12A | ZC3H12A | 50.3 |
| CD83 molecule | CD83 | 3.06 |
| Zinc finger protein 36, C3H type, homolog (mouse) | ZFP36 | 16.44 |