Skip to main content
. Author manuscript; available in PMC: 2010 Aug 23.
Published in final edited form as: Diabetes. 2007 Feb 22;56(5):1481–1485. doi: 10.2337/db06-1682

FIG. 3.

FIG. 3

Interaction between rs12255372 and percentage of body fat on β-cell compensation, computed as the product of SI × 30′ Δinsulin concentration (DI30). A: Median age- and sex-adjusted DI30 and interquartile range stratified by genotype and percentage of body fat tertiles. Within the lowest body fat tertile, individuals homozygous for the G allele have higher adjusted DI30 compared with individuals with at least one copy of the T allele. However, within the highest body fat tertile, individuals homozygous for the G allele have lower adjusted DI30. The effect of adiposity to alter DI30 is greater among subjects homozygous for the G allele compared with those with at least one copy of the T allele. B: Interaction based on the model parameter estimates and covering the range of body fat observed in the BetaGene Study.