Table 1.

Selected Examples of AD Mouse Models.

Line	Promoter	FAD Mutation	Amyloid Pathology	Reference
PDAPP	PDGF	APP-Indiana	Parenchymal plaques at 6–9 months of age	12
Tg2576	PrP	APP-Swedish	Parenchymal plaques by 11–13 months of age with some vascular amyloid	16
APP23	Thy-1	APP-Swedish	Parenchymal plaques by 6 months of age and prominent vascular deposition of amyloid	18
TgCRND8	PrP	APP-Swedish + Indiana	More aggressive parenchymal plaque pathology present by 3 months of age	17
APP-Dutch	Thy-1	APPE693Q associated with hereditary cerebral hemorrhage with Dutch-type amyloidosis	Vascular deposition of amyloid with few parenchymal plaques	47
PS1M146V	PDGF	PS1M146V	Elevated Aβ42 without plaque pathology	24
PSAPP	PS1M146V × Tg2576	PS1M146V + APP-Swedish	Earlier and more extensive plaque pathology in comparison with Tg2576 alone	30
3×Tg	Thy-1.2 and native mouse	Transgenes containing Thy-1.2–driven APP-Swedish and tau P301L were coinjected onto a homozygous PS1M146V knock-in background.	Parenchymal plaques by 6 months of age combined with tau pathology by 12 months of age	63

NOTE: Additional information on AD Tg models can be found at the Web site of the Alzheimer’s Association (http://www.alzforum.org/res/com/tra).

Abbreviations: Aβ, β-amyloid; AD, Alzheimer’s disease; APP, amyloid precursor protein; FAD, familial Alzheimer’s disease; PDAPP, platelet-derived growth factor promoter driving amyloid precursor protein; PDGF, platelet-derived growth factor β; PrP, prion protein; PS1, presenilin 1; PSAPP, presenilin/amyloid precursor protein; Tg, transgenic.