Fig. 4.

Reduced rate of gain in body length, total body bone mineral density (BMD), and total body bone mineral content (BMC) in conditional mutant mice during prepubertal growth. Growth and bone parameters were determined by dual X-ray absorptiometry analysis and rate of gain was calculated between 2 and 4 wk of age. Data are expressed as conditional mutants as a percent of controls and presented as means ± SE. *Significant difference from controls at P < 0.05. At 2 wk of age [conditional mutant female mice (n = 6), conditional mutant male mice (n = 4), control female mice (n = 4), control male mice (n = 4)]. At 4 wk of age, n = 8 mice/sex/treatment group.