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Schematic representation of predicted miRNA-binding sites at the PLAG1 3′UTR. CLL-specific deregulated miRNAs were applied to TargetScan 4.1–based prediction of miRNA-binding sites for identification of putative targets genes. PLAG1 gene was identified to harbor multiple binding sites of CLL-specific deregulated miRNAs. Evolutionarily highly conserved (including chicken) miRNA-binding sites of 3′UTR are indicated in black; less conserved binding sites, in gray.
