Table 3.

Deregulated miRNAs in CLL versus healthy donor B cells

miRNA	Mean expression of CLL cells	Mean expression of healthy B cells	Fold change	P	Absolute difference of means
hsa-miR-107	692.53	1764.03	−2.55	< .001*	1071.5
hsa-miR-125a	418.88	2039.2	−4.87	< .001*	1620.32
hsa-miR-126	4540.85	15 815.12	−3.48	< .001*	11 274.27
hsa-miR-126*	1983.83	21 761.79	−10.97	< .001*	19 777.95
hsa-miR-130a	1272.19	10 530.37	−8.28	< .001*	9258.18
hsa-miR-139	1001.53	3095.88	−3.09	< .001*	2094.35
hsa-miR-141	3871.12	1623.27	2.38	< .001*	2247.85
hsa-miR-143	299.48	1506.67	−5.03	< .001*	1207.19
hsa-miR-148a	14 042.43	4724.08	2.97	< .001*	9318.35
hsa-miR-155	26 073.76	9956.07	2.62	< .001*	16 117.69
hsa-miR-181a	1093.34	9251.04	−8.46	< .001*	8157.7
hsa-miR-181b	316.23	1364.86	−4.32	< .001*	1048.63
hsa-miR-199a	386.26	4393.66	−11.37	< .001*	4007.4
hsa-miR-199a*	1511.02	8537.04	−5.65	< .001*	7026.02
hsa-miR-326	222.65	3376.34	−15.16	< .001*	3153.69
hsa-miR-34a	1876.1	444.46	4.22	< .001*	1431.64
hsa-miR-368	270.28	2118.85	−7.84	< .001*	1848.57
hsa-miR-369-3p	294.96	1307.95	−4.43	< .005*	1012.99
hsa-miR-424	902.62	2536.33	−2.81	< .002*	1633.71
hsa-miR-449	1713.84	5159.03	−3.01	.002	3445.2
hsa-miR-451	16 872.23	5770.64	2.92	< .001*	11 101.59
hsa-miR-565	2861.11	8192.31	−2.86	.003	5331.2
hsa-miR-582	333.08	1793.82	−5.39	< .001*	1460.74
hsa-miR-584	344.23	2809.91	−8.16	< .001*	2465.68
hsa-miR-598	2010.3	910.88	2.21	< .001*	1099.42
hsa-miR-660	2000.38	896.36	2.23	< .001*	1104.02

BeadChip microarray–based miRNA expression values of quantile normalized data comparing purified CLL cells (n = 50) to healthy donor peripheral B cells (n = 14). A t test was carried out for determination of differential expression. For rigid correction of multiple testing, Bonferroni correction was applied and miRNAs remaining significant by this test are indicated by asterisks (*).