Fig. 1.

Aβ-induced paralysis in C. elegans strain CL2006 fed with antidepressants. (A) Effect of fluoxetine at concentration of 1, 10, 100, 1000 μM on Aβ-induced paralysis. (B) Effect of citalopram at concentration of 10, 100, 1,000 and 2,000 μM on Aβ-induced paralysis. (C) Effect of paroxetine at concentration of 10 nM, 100 nM, 1 μM, 10 μM and 100 μM. Synchronized eggs of CL2006 C. elegans were maintained at 20 °C, on the 35×10 mm culture plates (~35 eggs/plate) containing vehicle (control) or drugs. The treatment was given to the worm from egg stage onward until the worm completely paralyzed.(35 worms in each experiment, 3 independent experiments).