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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Neurobiol Dis. 2010 May 26;40(1):193–199. doi: 10.1016/j.nbd.2010.05.024

Figure 5.

Figure 5

Seizures return after cessation of rapamycin administration. Rats with spontaneous recurrent seizures were first treated with rapamycin (black bar) or vehicle (open bar) for three weeks. Seizure activity was monitored for an additional three weeks after stopping rapamycin treatment and quantified according to average number of seizures(A) (pilocarpine: 31.5 ± 14.23; pilocarpine plus rapamycin: 13.67 ± 6.82), average total seizure duration(B) (pilocarpine: 751.67± 324.68; pilocarpine plus rapamycin: 341.5 ± 176.89) and the percentage of rats with at least one seizure(C) (pilocarpine: 100; pilocarpine plus rapamycin:83.3%). (n=6 per group).