Table 3.
Multivariable regression analyses for selected variables
| Variable | N | Chronic GVHD |
DFS |
Relapse |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | ||
| Phase of disease | ||||||||||
| CR2 | 12 | 0.3 | 0.1–0.7 | 0.008 | 0.3 | 0.1–0.8 | 0.02 | |||
| First untreated relapse | 11 | 0.5 | 0.2–1.2 | 0.14 | 0.4 | 0.1–1.0 | 0.06 | |||
| Refractory relapse | 35 | 1 | — | — | 1 | — | — | |||
| Marrow cytogenetics | ||||||||||
| Normal | 27 | 1 | — | — | 1 | — | — | |||
| Abnormal | 31 | 2.7 | 1.4–5.3 | 0.003 | 2.7 | 1.3–5.6 | 0.008 | |||
| Preparative regimen | ||||||||||
| Non-TBI containing | 9 | 1 | — | — | ||||||
| TBI containing | 47 | 6.8 | 0.9–51.3 | 0.06 | ||||||
| Time from diagnosis to BMTa | 58 | 1.6 | 1.3–1.96 | 0.02 | ||||||
GVHD = graft-versus-host disease; DFS = disease-free survival; CR2 = second remission; TBI = total body irradiation; BMT = bone marrow transplant; HR = hazard ratio; CI = confidence interval.
a
Modeled as a continuous linear variable. The HR is presented as an increase in 1 year.