Figure 2.

The active site in S3P-liganded EPSP synthase. Strictly conserved residues are highlighted yellow. Noncarbon atoms are color-coded with blue for nitrogen, red for oxygen, and magenta for phosphorus. Light-blue spheres designate solvent molecules. Hydrogen bonds and ionic interactions are indicated by thin and thick dashed lines, respectively. Tyr-200, which is in hydrophobic contact with the cyclohexenyl moiety of S3P, is not shown. (a) In the absence of glyphosate (stereo view). S3P, formate, and phosphate are shown in green. (b) In the presence of glyphosate (stereo view). S3P and glyphosate are shown in green. (c) Final 2F_o − F_c electron density map of the EPSP synthase⋅S3P⋅glyphosate complex to 1.5-Å resolution contoured at 1σ (stereo view). Drawn with bobscript (24).