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. 2010 Apr 12;38(15):4970–4984. doi: 10.1093/nar/gkq245

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 10. — A model for SRAF and SC. (A) A model for the repressed state, where SUMO-conjugation disrupts the interaction with the co-activator. (B) A model for the repressed state where multiple SUMO-conjugated factors recruit a multivalent co-repressor; SCF, synergy control factor (9). (C) Traditional concept of synergy mediated by joint recruitment of a multivalent co-activator. (D) Current model for the activated state where multiple AFs (depicted as stars) per transcription factor lead to more efficient recruitment of a multivalent co-activator. (E) A variant of the model above (D) where different AFs may interact with different co-activators.