Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Apr 19;38(15):5242–5259. doi: 10.1093/nar/gkq258

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 4. — PR gene expression can be silenced by agRNAs containing 2′OMe-RNA. (A) Duplex sequences: passenger strands are listed on top in all cases; for siRNA PR2526 this is the sense strand, but for agRNAs PR-9 and PR-26 this is the antisense strand. Modification codes: dna, RNA, 2′Ome-rna. (B) PR-9 analogs and controls containing 2′OMe-RNA. (C) PR-26 analogs containing 2′OMe-RNA. All data are normalized to mismatch control MM4. RNA levels are the average (±SD) from at least two independent transfections. *P < 0.05, **P < 0.01, ***P < 0.005. Protein levels were also confirmed by at least two independent transfections, from which a typical western blot is shown.