Table 2.

IC₅₀ values for PR-9 and modified analogs in T47D cells^a

Silencing agRNA	Type of chemistry	IC50 (RNA) (nM)	IC50 (protein) (nM)
PR9	native	5.6	12.2
PR9 NZ	2′F	18.6	19.6
PR9 JpJ	2′OMe	9.4	10.2
PR9 PN	2′OMe	12.9	12.6
PR9 NL	LNA	6.8	13.2
PR9 L5N	LNA	13.3	7.4

^aPlots used to derive these data are shown in Supplementary Figures S3 and S4.