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. Author manuscript; available in PMC: 2011 Jun 15.
Published in final edited form as: J Immunol. 2010 May 14;184(12):7154–7161. doi: 10.4049/jimmunol.0902514

FIGURE 1.

FIGURE 1

Lupus serum induces skin inflammation. A, Representative histopathologic photomicrograph of skin of C57BL/6 mice sacrificed 3 d after intradermal inoculation of serum (100 μl) from a lupus patient with skin disease (SLE15, left panel), a lupus patient without skin disease (SLE6, middle panel), and a healthy control (right panel). Infiltration of mononuclear cells and proliferation of keratinocytes are apparent in the skin following intradermal injection of lupus serum. H&E, original magnification ×10. B, Kinetics of skin inflammation induced by serum from a lupus patient (SLE15) with skin disease and a healthy control. C, The severity of skin inflammation induced by various volumes of lupus serum from a patient (SLE12) with skin disease 3 d after intradermal injection. D, Severity and incidence of skin inflammation induced by lupus patients with (n = 6) or without (n = 12) skin disease and SLEDAI > 4 (n = 7) or SLEDAI ≤ 4 (n = 10). E, Histopathology of skin inflammation 3 d after intradermal injection of serum (100 μl) from lupus-prone MRL/lpr mice with skin injury and normal C57BL/6 mice or PBS (100 μl). H&E, original magnification ×10.