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. Author manuscript; available in PMC: 2011 Jun 15.
Published in final edited form as: J Immunol. 2010 May 14;184(12):7154–7161. doi: 10.4049/jimmunol.0902514

FIGURE 4.

FIGURE 4

The role of IgG in lupus serum-induced skin inflammation. A, Severity and representative photomicrograph of skin inflammation 3 d after intradermal inoculation of 100 μl lupus serum (SLE1) with or without IgG depletion. *p <0.05. B, Incidence of skin inflammation 3 d after intradermal inoculation of serum (100 μl) from lupus-prone MRL/lpr mice (16 wk old) and normal C57BL/6 mice (16 wk old) in MRL/lpr mice (6 wk old) and C57BL/6 mice (6 wk old). C, Immunofluorescent staining of IgG deposition in skin lesion of MRL/lpr mouse at age 21 wk (left panel) and skin of normal C57BL/6 mice with intradermal injection of serum from MRL/lpr mice at age 21 wk (middle panel) or from normal C57BL/6 mice (right panel). Original magnification ×20.