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. Author manuscript; available in PMC: 2011 Jun 15.
Published in final edited form as: J Immunol. 2010 May 14;184(12):7154–7161. doi: 10.4049/jimmunol.0902514

FIGURE 6.

FIGURE 6

Expression of MCP-1 and NF-κB in lupus serum-induced skin inflammation. A, Immunohistochemical staining for TNFR1 and TNFR2 expression in skin lesions 3 d after intradermal inoculation of serum (100 μl) from a lupus patient (SLE1) in C57BL/6 mice. Immunohistochemical staining shows NF-κB (B) and MCP-1 (C) expression in skin lesions 3 d after intradermal injection of serum from a lupus patient (SLE15) and a healthy control in C57BL/6 mice. Anti-human IgG Ab was used as control staining. A–C, H&E, original magnification ×10. D, Severity and incidence of skin inflammation induced by serum from a lupus patient (SLE4) in MCP-1–deficient mice (n = 5) and wild type mice (n = 5). *p < 0.05.