Table 2.

Regression Analyses for Neuroanatomic and Neuropathological Variables on Psychiatric and Cognitive Measures

Outcome Measure	r Value	Regression Coefficient (SE)	P Value
Neuroanatomic Outcomes
CA3 neuron density
Anxiety-depression index	0.05	2738 (6414)	.67
Anxiety Trait Scale score	0.04	462 (1274)	.72
Depressiona	0.05	1524 (3850)	.69
Global cognition index	−0.14	−7192 (6248)	.25
Episodic memory score	−0.05	−5049 (4134)	.23
CA3 MAP2 dendrite index
Anxiety-depression index	−0.25	−0.13 (0.06)	.03
Anxiety Trait Scale score	−0.31	−0.03 (0.01)	.009
Depressiona	−0.12	−0.39 (0.37)	.29
Global cognition index	0.21	0.10 (0.06)	.09
Episodic memory score	0.17	0.06 (0.04)	.16
CA3 synaptopodin spine index
Anxiety-depression index	−0.38	−11.5 (3.3)	<.001
Anxiety Trait Scale score	−0.33	−1.97 (0.67)	.004
Depressiona	−0.35	−6.31 (2.02)	.003
Global cognition index	0.10	3.05 (3.52)	.39
Episodic memory score	0.10	1.91 (2.33)	.41
Neuropathological Outcomes
CA1/subiculum PHF-tau neurofibrillary tangle densityb
Anxiety-depression index	−0.17	−4.2 (2.8)	.15
Anxiety Trait Scale score	−0.10	−0.52 (0.56)	.36
Depressiona	−0.21	−2.87 (1.69)	.09
Global cognition index	−0.42	−0.01 (0.004)	.007
Episodic memory score	−0.50	−0.02 (0.006)	<.001
CA1/subiculum β-amyloid senile plaque densityb
Anxiety-depression index	−0.05	−0.08 (0.18)	.66
Anxiety Trait Scale score	−0.07	−0.02 (0.04)	.59
Depressiona	−0.03	−0.03 (0.10)	.80
Global cognition index	−0.16	−0.12 (0.07)	.10
Episodic memory score	−0.30	−0.33 (0.12)	.005

Abbreviations: MAP2, microtubule-associated protein 2; PHF-tau, paired helical filament tau.

^aDetermined with the use of the Center for Epidemiological Studies Depression Scale.

^bAdjusted for age and education.