Table 2.

Baseline scores on cognitive tests by genotype of the 3 polymorphisms and the interaction at baseline between the polymorphisms and ACEINH exposure.

Caucasians
ACE-ID	D/D	I/D	I/I	p-value, genotype differences	p-value, ACEINH × Gene interaction
CLOX1	11±0.1	10.9±0.1	11±0.13	0.78	0.90
DSST	41.3±0.4	40.7±0.4	40.3±0.6	0.16	0.49
3MSE	93.0±0.24	93.0±0.2	92.7±0.3	0.45	0.37
AGT6	A/A	A/G	G/G
CLOX1	11.1±0.1	10.9±0.1	10.8±0.1	0.01	0.11
DSST	41.7±0.6	41.1±0.4	39.8±0.4	0.01	0.55
3MSE	93.1±0.3	92.9±0.2	92.950.2	0.94	0.19
AGTM235T	C/C	C/T	T/T
CLOX1	11.1±0.1	10.9±0.1	10.8±0.1	0.004	0.04
DSST	41.5±0.6	41.0±0.4	40.0±0.4	0.05	0.14
3MSE	93.1±0.3	92.8±0.12	92.9±0.2	0.95	0.31
African Americans
ACE-ID	D/D	I/D	I/I
CLOX1	10.01±0.1	10.1±0.1	10.3±0.1	0.67	0.41
DSST	27.4±0.6	27.4±0.5	27.6±0.8	0.86	0.21
3MSE	86.1±0.4	85.9±0.3	85.6±0.6	0.43	0.69
AGT6	A/A	A/G	G/G
CLOX1	10.0±0.1	10.3±0.1	10.4±0.4	0.09	0.76
DSST	26.9±0.4	28.0±0.6	30.0±1.9	0.03	0.69
3MSE	85.6±0.3	86.6±0.4	87.4±1.3	0.005	0.060
AGTM235T	C/C	C/T	T/T
CLOX1	10.1±0.1	10.1±0.1	10.6±0.3	0.22	0.97
DSST	27.0±0.4	27.9±0.6	28.3±1.7	0.19	0.45
3MSE	85.7±0.3	86.2±0.4	87.2±1.2	0.04	0.08

CLOX1: Executive clock draw test; DSST: Digit Symbol Substitution Test; 3MSE: Modified Mini Mental Status Examination;; Numbers are least square means ± standard error obtained from the multivariate models after adjusting for age, gender, BMI, education, systolic blood pressure and stroke