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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: J Am Geriatr Soc. 2010 Jun;58(6):1035–1042. doi: 10.1111/j.1532-5415.2010.02860.x

Table 3.

Interaction between ACEINH and longitudinal cognitive function change in the Health ABC participants

p-value for ACEINH × Gene interaction on cognitive decline
Caucasians African Americans
ACE-ID
CLOX1 0.39 0.97
DSST 0.46 0.14
3MSE 0.46 0.14
AGT6
CLOX1 0.01 0.45
DSST 0.22 0.06
3MSE 0.22 0.06
AGTM235T
CLOX1 0.01 0.64
DSST 0.15 0.12
3MSE 0.15 0.12

CLOX1: Executive clock draw test; DSST: Digit Symbol Substitution Test; 3MSE: Modified Mini Mental Status Examination; p-values are obtained from the Multivariate Mixed Models testing the hypothesis that the gene × ACEINH is significant on the longitudinal change in the cognitive test over the follow-up period. All models adjusted for age, sex, BMI, educational level, systolic blood pressure, stroke, APOE haplotypes, diabetes, baseline CLOX1 scores, and exposure to other high blood pressure medications.