Fig. 4.
Pretreatment with BW245C does not affect mouse core body temperature. BW245C (10 nmol) was injected ICV, and the body temperatures of the mice (n = 6 per group) were recorded with an intra-abdominal radiofrequency probe every 10 min during the first 120 min after injection and then once daily for 4 days while the mice were housed at room temperature. No significant differences in core body temperature were observed between the saline-treated and BW245C-treated groups