Fig. 9.

Representative photomicrographs of colocalization of apoE and GFAP and apoE and Aβ. a Photomicrograph from adult rhesus macaque demonstrating little overlap of GFAP and apoE from the PFC. b Photomicrograph from an aged rhesus macaque from the PFC. GFAP immunoreactivity (red) and apoE immunoreactivity (green) in the same image. Yellow areas are the overlap of GFAP and apoE immunoreactivity. cWhite boxed area from b enlarged to demonstrate the lack of colocalization of GFAP and apoE. White arrow indicates apoE immunoreactivity in close proximity, but not overlapping with GFAP immunoreactivity. Furthermore, GFAP grouping around apoE positive clusters are observed. d Photomicrograph from an aged rhesus macaque of an Aβ cluster that is not apoE positive from the PFC. e Photomicrograph from an aged rhesus macaque of an Aβ and apoE positive cluster from the PFC. Overlapping of Aβ and apoE immunoreactivity shows yellow. Scale bar is 30 µm