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The designed e–g salt bridges stabilizing the conformations for DSD and DSAg. + indicates a positively charged Lys side chain; − indicates a negatively charged Glu side chain. Colored cylinders represent the α-helical domains. Notice DSD contains only two functional units, and the DSAg fibril can contain an unlimited number of functional units because the C-terminal domain of each monomer is always available to bind an additional molecule.
