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Fpn1ffe/ffe mutant embryos exhibit NTDs. (A-D) Lateral view of wild-type (A,C) and Fpn1ffe/ffe mutant (B,D) embryos at E12.5 (A,B) and E14.5 (C,D). Mutant embryos are developmentally delayed, and exhibit exencephaly, microphthalmia and generalized edema. Lateral views of embryos with anterior towards the left.
