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Protandim® increases plasma PON1 normalized to the mean for age-matched control diet animals. At 6 weeks, Protandim®-supplemented animals averaged 30.1 ± 2.6 U/ml or 35% more than control diet group (22.3 ± 3.1 U/ml). Similarly, at 6 months, Protandim-supplemented animals averaged 11.7 ± 1.4 U/ml or 36% more than control diet group (8.6 ± 1.1 U/ml), even though plasma PON1 activity dropped for both groups from 6 weeks to 6 months.
