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. 2010 Jun 15;18(8):1450–1457. doi: 10.1038/mt.2010.115

Figure 7.

Figure 7

Amphetamine-induced rotation at 4 weeks postinjection. (a) Injection with α-synuclein (α-syn) small-interfering RNA (siRNA) induced significant rotation ipsilateral to the injected side for si-312 in a 60-minute period after amphetamine injection. Group statistics were F(6,50) = 6.038, P < 0.0001, Tukey's post hoc: ***P < 0.001 versus control siRNA (rds or rhodopsin), ##P < 0.01 versus si-312+rat syn. There were no other significant differences between groups; N = 4–12 for each group. (b) Time course of amphetamine-induced rotation at 4-week time point for green fluorescent protein (GFP) (closed grey squares), myocardin (closed grey circle), si-312 (open circles), and si-163 (open squares). Net rotation for each group is shown for each 10-minute interval following treatment with amphetamine. Positive rotation indicates rotation toward the injected side; negative rotation indicates rotation contralateral to the injected side. Two-way analysis of variance statistics: time: F (9,297) = 1.20, P = 0.298; gene: F(3,297) = 64.1, P < 0.0001; time × gene interaction: F (24,297) = 0.571, P = 0.949. Bonferroni post-tests are indicated as *P < 0.05, **P < 0.01, ***P < 0.001. Asterisks indicate that the group is being compared to the GFP or myocardin group in the same time bin; N = 5–12 for each group.