Figure 1.

Lesion/graft site after primate C7 hemisection. Thionin-stained transverse (A, B) and horizontal (C, D) sections through monkey spinal cord lesion site 8 months after C7 lateral hemisection (the dashed line indicates lesion border). In both nongrafted subjects (A, C) and subjects grafted with autologous fibroblasts genetically modified to secrete BDNF and NT-3 (B, D), cells fill the lesion site. Cells are both rounded and spindle-shaped, typical of fibroblast, Schwann cells, and leptomeningeal cell morphology (Fig. 2). Higher magnification insets in E and F reveal greater density cell within grafted subjects. Scale bars: B (for A, B), D (for C, D), 1 mm; F (for E, F), 50 μm; inset, 10 μm.