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Neurotrophin-secreting grafts do not promote CST regeneration. Shown are photomicrographs of horizontal spinal cord sections: rostral, left; caudal, right (dashed line indicates lesion interface). A–D, Transected CST axons anterogradely labeled with dextran-488 do not enter the cellular matrix of either ungrafted lesion site (A, C) or lesion site containing fibroblasts that secrete BDNF and NT-3 (B, D). Scale bars: B (for A, B), 250 μm; D (for C, D), 100 μm.
